HES6-1 and HES6-2 Function through Different Mechanisms during Neuronal Differentiation

genes are not yet understood. genes, in contrast with overexpression of cHES6-2, which represses the same genes. We show that this activity of cHES6-2 is dependent on its capacity to bind DNA and repress transcription, while cHES6-1 seems to function by sequestering other HES proteins and inhibit their activity as transcriptional repressors. genes, cHES6-1 acts later, sequestering HES proteins. Together, the two cHES6 proteins progressively shut down the Notch-mediated progenitor program and ensure that neuronal differentiation can proceed

Economia doméstica: uma abordagem aplicada ao Programa de Educação de Jovens e Adultos do IFSC Campus São José

Anais do 35º Seminário de Extensão Universitária da Região Sul - Área temática: EducaçãoÉ muito importante para qualquer família controlar seus gastos domésticos evitando-se perder o controle das contas, pois três em cada quatro famílias brasileiras encontram dificuldades em chegar ao final do mês somente com recursos financeiros recebidos. Assim, percebe-se a necessidade de introduzir a Economia Doméstica na educação básica brasileira, em especial, nos ensinos fundamental e médio. Este trabalho abordará a Economia Doméstica na forma de projeto, em uma turma de Educação de Jovens e Adultos do Ensino Médio (PROEJA), com o objetivo de tornar mais fácil para os participantes a tomada de decisão, a partir do aprendizado sobre como planejar e gerenciar o orçamento doméstico. Foram planejados, em conjunto com os professores do curso, doze encontros presenciais com a turma no decorrer do semestre 2017/1, proporcionando a integração e tornando mais atrativa a abordagem nas categorias escolhidas, são elas: alimentação, habitação e transporte. Dentro de cada uma delas foram abordados temas adaptados às disciplinas regulares no decorrer do projeto. Os resultados foram satisfatórios, uma vez que todos perceberam a importância de planejar e de controlar seu orçamento familiar periodicamente, bem como a necessidade de alteração de seu comportamento de consumo para evitar inadimplência. O projeto revelou que todos os alunos já se depararam com dúvidas ao tomar decisões financeiras, logo uma abordagem aproximando a realidade vivenciada por eles foi a forma encontrada para facilitar a aprendizagem, analisando as categorias apresentadas, quebrando “mitos” e diferenciando a real necessidade do desejo de comprar. Por fim, considerando o feedback da turma, enfatiza-se a importância de dar continuidade nesse projeto de modo que possa vir a ser incorporado na grade curricular do PROEJA, como componente curricular obrigatória, pois é onde se concentra o maior impacto social devido à autonomia libertadora que a educação pode proporcionar na vida do alun

VEHICLE DYNAMICS ANALYSIS IN A FORMULA STUDENT RACING CAR

One of the most important concepts in motorsport is vehicle dynamics. Being able to predict the manoeuvre behaviour of a racing vehicle, not only reduces test time but also optimizes the development process. Once it is possible to isolate external factors, one can study a particular group of variables and anticipate their consequence on the overall vehicle performance. This work is focused on two different approaches to the problem of predicting vehicle behaviour. The first procedure consisted in the development of a simulation tool, more precisely, a Lap Time Simulator using Simulink. Given the specific requirements of the team, the simulator was built without the use of any predefined vehicle dynamics block sets, this means, the algorithm is fully customizable. The developed simulator uses a single point mass approach, so the vehicle body was converted to a single point neglecting the effects of body roll and load transfer. Nevertheless, the algorithm can predict the effects of different vehicle systems on lap time. The calculations include, for example, a powertrain model defined by engine torque, gear ratios, rotational inertia and fuel consumption. The aerodynamic module controls the negative lift and drag force present at each step. The tyre behaviour was defined by a basic tyre model, which predicts longitudinal, lateral and rolling resistance forces. The second method utilizes a commercially available solution using a quasi-steadystate approach with optional transient properties. Instead of a single point mass, the vehicle body model uses a four-track model with the motion of each wheel/suspension to formulate the vehicle manoeuvre. The tyre model was extended to include slip angle, slip ratio and combined slip. For that purpose, the software utilizes the Pacejka magic formula with formula student tyre data. One of the most important factors of simulation tools is the validation of the results. For that reason, the thesis also includes an experimental procedure regarding the behaviour of a formula student on a controlled environment track. The obtained data were used to compare the simulation results with the real logged data provided by a vehicle instrumentation apparatus

The Bruhat order on classes of isotopic latin squares

UIBD/MAT/00297/2020 UID/MAT/00212/2019In a previous paper, the authors introduced and studied the Bruhat order in the class of Latin squares of order n. In this paper, we investigate the restriction of the Bruhat order in a class of isotopic Latin squares. We present equivalent conditions for two Latin squares be related by the Bruhat order when one of them is obtained from the other by interchanging rows or columns or symbols. The cover relation is also addressed, and we present orthogonal isotopic Latin squares related by the Bruhat order.authorsversionpublishe

On the little secondary bruhat order

CMA and Departamento de Matematica da Faculdade de Ciencias Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.([email protected]).Partially supported by the Fundacao para a Ciencia e a Tecnologia through the project UID/MAT/04721/2019. Departamento de Matematica da Universidade da Beira Interior, Rua Marques D'Avila and Bolama, 6201-001 Covilha, Portugal ([email protected]).Partially supported by the Fundacao para a Ciencia e a Tecnologia through the project UIDB/MAT/00212/2020.Let R and S be two sequences of positive integers in nonincreasing order having the same sum. We denote by A(R, S) the class of all (0, 1)-matrices having row sum vector R and column sum vector S. Brualdi and Deaett (More on the Bruhat order for (0, 1)-matrices, Linear Algebra Appl., 421:219{232, 2007) suggested the study of the secondary Bruhat order on A(R, S) but with some constraints. In this paper, we study the cover relation and the minimal elements for this partial order relation, which we call the little secondary Bruhat order, on certain classes A(R, S). Moreover, we show that this order is different from the Bruhat order and the secondary Bruhat order. We also study a variant of this order on certain classes of symmetric matrices of A(R, S).publishersversionpublishe

TorKameleon: Improving Tor's Censorship Resistance With K-anonymization and Media-based Covert Channels

Anonymity networks like Tor greatly improve online privacy but are susceptible to correlation attacks from state-level adversaries and Internet censors. To enhance privacy, covert channels encapsulated in media protocols, particularly WebRTC-based encapsulation, have shown promise against passive traffic correlation attacks. However, their effectiveness against active correlation attacks has not been explored, and compatibility with Tor remains limited. This paper introduces TorKameleon, a censorship evasion solution that protects Tor users from passive and active correlation attacks. It incorporates K-anonymization techniques to fragment and reroute traffic through multiple paths formed by multiple proxies and uses covert WebRTC-based channels or TLS tunnels to encapsulate user traffic. The developed prototype has undergone extensive validation for performance and resilience against correlation attacks, showcasing its effectiveness

Classes of (0,1)-matrices Where the Bruhat Order and the Secondary Bruhat Order Coincide

FCT (UID/MAT/00212/2019) FCT (UID/MAT/00297/2019)Given two nonincreasing integral vectors R and S, with the same sum, we denote by A(R, S) the class of all (0,1)-matrices with row sum vector R, and column sum vector S. The Bruhat order and the Secondary Bruhat order on A(R, S) are both extensions of the classical Bruhat order on Sn, the symmetric group of degree n. These two partial orders on A(R, S) are, in general, different. In this paper we prove that if R = (2,2,…,2) or R = (1,1,…,1), then the Bruhat order and the Secondary Bruhat order on A(R, S) coincide.authorsversionpublishe

Latin Squares and their Bruhat Order

In this paper we investigate the Bruhat order on the class of Latin squares. We study its cover relation and minimal elements. We prove that the class of Latin squares of order $n$, with $n\not\in\{1,2,4\}$, has at least two minimal elements, and we present a process to construct some minimal Latin squares for this relation

Neuromesodermal progenitors and the making of the spinal cord

Neuromesodermal progenitors (NMps) contribute to both the elongating spinal cord and the adjacent paraxial mesoderm. It has been assumed that these cells arise as a result of patterning of the anterior neural plate. However, as the molecular mechanisms that specify NMps in vivo are uncovered, and as protocols for generating these bipotent cells from mouse and human pluripotent stem cells in vitro are established, the emerging data suggest that this view needs to be revised. Here, we review the characteristics, regulation, in vitro derivation and in vivo induction of NMps. We propose that these cells arise within primitive streak-associated epiblast via a mechanism that is separable from that which establishes neural fate in the anterior epiblast. We thus argue for the existence of two distinct routes for making central nervous system progenitors